Category Archives: Adenosine, Other

S4and Fig. work establishes a molecular link between MALT lymphoma and ABC-DLBCL, and provides mouse models to test MALT1 inhibitors. Finally, our results suggest that hematopoietic stem/progenitor cells may be involved in the pathogenesis of human mature B-cell lymphomas. infection, and also in the ocular adnexa, lung, salivary glands, intestinal tract, skin, thyroid, and genitourinary tract, and are associated with chronic microbial infections or autoimmune disorders. MALT lymphomas show a typical histopathological picture composed of a heterogeneous neoplastic B-cell population that arises from the marginal zone of reactive B-cell follicles, extends to the interfollicular region, and infiltrates the epithelium, forming the characteristic lymphoepithelial lesions. Additionally, these lymphomas frequently show a prominent plasmacytic differentiation (1C3). Genetically, MALT lymphomas are mainly associated with two chromosomal translocations involving the gene. The t(11;18)(q21;q21), which generates an API2-MALT1 fusion transcript, occurs in up to 30% of the cases, whereas the t(14;18)(q32;q21) results in the immunoglobulin…

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