Category Archives: Amylin Receptors

1999). Acknowledgments We thank Dr. rapidly upon the induction of myogenic differentiation. The presence of phosphorylation in a region of Pax3 important for mediating proteinCprotein interactions, and the fact that phosphorylation is lost upon induction of differentiation, allow for speculation on the biological relevance of phosphorylation. mice are embryonic lethal due to defects in skeletal muscle (Xia and Barr 2005), and human patients AZD3514 with haploinsufficiency display limb muscle hypoplasia (Epstein et al. 1996). It has been demonstrated that the ectopic expression of Pax3 is capable of activating the myogenic program in mesoderm tissue by activating the expression of the myogenic regulatory factors MyoD, Myf-5, and myogenin (Maroto et al. 1997). Because of the importance of Pax3 in early muscle development and in the expression of early myogenic genes, it is critical that the expression and activity of Pax3 be tightly regulated throughout differentiation. Recently, it was determined that the…

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[PubMed] [Google Scholar]Zahrt J, Taylor JR, Mathew RG, Arnsten AF. that bilateral infusion of APV into the medial prefrontal cortex prior to testing significantly improved both sets of behaviors in gonadectomized rats and significantly worsened performance measures in gonadally intact controls. In hormone-replaced cohorts, we further found that behaviors that are normally similar to controls were significantly disrupted by APV, and those that are normally similar to gonadectomized rats were rescued by intracortical APV infusion. There were, however, no residual effects of APV on retention testing conducted 24 hours later. Together these findings suggest that hormone regulation of NMDAR-mediated activity specifically within the PFC may be fundamental to the effects of gonadal steroids on spatial cognition in males. Our findings further identify NMDAR antagonists as potentially novel, nonsteroidal means of attenuating the cognitive deficits that can accompany gonadal hormone decline in human males in aging, clinical cases of hypogonadalism and…

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