Category Archives: Exocytosis

3i, ?,j,j, Extended Data Fig. However, the underlying mechanisms that initiate and sustain maladaptive swelling with ageing are not well defined. Here we display that in ageing mice myeloid cell bioenergetics are suppressed in response to improved signalling from the lipid messenger prostaglandin E2 (PGE2), a major modulator of swelling11. In ageing macrophages and microglia, PGE2 signalling through its EP2 receptor promotes the sequestration of glucose into glycogen, reducing glucose flux and mitochondrial respiration. This energy-deficient state, which drives maladaptive pro-inflammatory reactions, is further augmented by a dependence of aged myeloid cells on glucose as a principal fuel resource. In aged mice, inhibition of myeloid EP2 signalling rejuvenates cellular bioenergetics, systemic and mind inflammatory claims, hippocampal synaptic plasticity and spatial memory space. Moreover, blockade of peripheral myeloid EP2 signalling is sufficient to restore cognition in aged mice. Our study suggests that cognitive ageing is not a static or irrevocable Madecassoside…

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